The most common cause of non-healing is spasming of the internal Anal sphincter muscle which results in impaired blood supply to the anal mucosa.The result is a non-healing ulcer, which may become infected by fecal bacteria.

Fissures look much like a paper cut.

Fissures may be caused by

• Prolonged diarrhea
• Constipation
• Prolonged diarrhea
• Child birth trauma in women
• Crohn’s disease
• Anal sex
• Poor toileting